Description

5,6-Diamino-2-Thiouracil-13C,15N is a high-purity, stable isotope-labeled derivative of the heterocyclic compound 5,6-diamino-2-thiouracil. This compound is specifically designed for use as a critical internal standard and tracer in advanced analytical and metabolic research, providing unparalleled accuracy in quantification and pathway elucidation. It is an essential material for scientists and researchers in pharmaceutical development, forensic toxicology, and environmental analysis who require the highest level of precision and reliability in their mass spectrometry and NMR studies.

Application

• Internal Standard for LC-MS/MS: Used for the precise quantification of 5,6-diamino-2-thiouracil and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Metabolic Pathway Tracing: Enables detailed studies of drug metabolism, degradation pathways, and biochemical mechanisms in pharmacokinetic and pharmacodynamic research.
• Pharmaceutical Impurity Profiling: Assists in the identification and quantification of process-related impurities and degradation products in active pharmaceutical ingredient (API) development.
• Forensic and Doping Control Analysis: Provides a definitive reference standard for the accurate detection of thiouracil-derived compounds in forensic toxicology and anti-doping programs.
• Environmental Fate Studies: Used as a tracer to study the environmental breakdown and transformation of similar chemical structures.
• NMR Spectroscopy: Serves as a valuable probe for structural analysis and dynamic studies in solution-state NMR due to its 13C and 15N labels.

Basic Information

Product Name	5,6-Diamino-2-Thiouracil-13C,15N
CAS No.	1246816-80-7
Molecular Formula	C413CH4N315NOS
Molecular Weight	Contact for details
Synonyms	2-Thio-5,6-diaminouracil-13C,15N; 5,6-Diamino-2-mercapto-4-pyrimidinol-13C,15N; 5,6-Diamino-2-sulfanylidene-1H-pyrimidin-4-one-13C,15N; 2-Thio-5,6-diamino-4(1H)-pyrimidinone-13C,15N; Isotopically labeled 5,6-diamino-2-thiouracil; [13C,15N2]-5,6-Diamino-2-thiouracil; 5,6-Diamino-2-thioxodihydropyrimidine-4(1H)-one-13C,15N
EINECS	Contact for details

Quality Control

Every batch of 5,6-Diamino-2-Thiouracil-13C,15N is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing, including isotopic purity and chemical purity assays, to ensure compliance with the exacting standards required for analytical research. A comprehensive Certificate of Analysis (COA), detailing isotopic enrichment, chemical purity, and identity confirmation, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	Yellow to brown powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (13C)	≥ 99 atom %
Isotopic Purity (15N)	≥ 98 atom %
Water Content (KF)	≤ 2.0 %
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.