Description

Dehydro Norketamine-D4 is a deuterated analog of a key ketamine metabolite, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled compound is critical for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily utilized by pharmaceutical researchers, forensic toxicologists, and clinical laboratories engaged in pharmacokinetic studies, drug metabolism research, and precise bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of norketamine and related metabolites in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug disposition and metabolic pathways in preclinical and clinical research.
• Forensic Toxicology: Used in confirmatory testing and method validation for the detection of ketamine and its analogs in forensic casework.
• Bioanalytical Method Development: Serves as a critical reference material for developing and validating robust, GLP-compliant analytical methods.
• Pharmaceutical Quality Control: Supports impurity profiling and stability testing of ketamine-based pharmaceutical products.
• Research on NMDA Receptor Antagonists: A valuable tool for mechanistic studies involving glutamatergic signaling and neuropharmacology.

Basic Information

Item	Details
Product Name	Dehydro Norketamine-D4
CAS No.	1246816-68-1
Molecular Formula	C12H10D4ClNO
Molecular Weight	221.73 g/mol
Synonyms	2-(2-Chlorophenyl)-2-(methylamino)cyclohex-2-en-1-one-d4; NorKetamine-d4 (Dehydro); 2-Amino-2-(2-chlorophenyl)cyclohex-2-enone-d4; DNKT-d4; Deuterated Dehydro Norketamine; [D4]-Dehydro Norketamine; Internal Standard for Norketamine
EINECS	Contact for details

Quality Control

Our Dehydro Norketamine-D4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic enrichment (by MS), and related substances. We ensure compliance with relevant standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.