Description

3-Methoxy Acetaminophen-D3 is a deuterium-labeled analog of the pharmaceutical intermediate 3-Methoxy Acetaminophen, where three hydrogen atoms are replaced with the stable isotope deuterium. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, providing unmatched accuracy and reliability in analytical measurements. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics industries, where precise quantification of metabolites and drug compounds is critical.

Application

• Internal Standard for LC-MS/MS: Primary application for the accurate quantification of 3-Methoxy Acetaminophen and related metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track drug metabolism and establish bioavailability.
• Forensic Toxicology: Enables precise measurement of acetaminophen metabolites in forensic analyses for overdose cases or post-mortem investigations.
• Clinical Research: Supports studies on drug safety, efficacy, and personalized medicine by ensuring data integrity in biomarker analysis.
• Method Development & Validation: Critical for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Reference Material: Serves as a high-purity certified reference material (CRM) for instrument calibration and quality assurance programs.

Basic Information

Product Name	3-Methoxy Acetaminophen-D3
CAS No.	1246816-53-4
Molecular Formula	C9H8D3NO3
Molecular Weight	184.21 g/mol (approx.)
Synonyms	N-(4-Hydroxy-3-methoxyphenyl)acetamide-d3; 3'-O-Methylacetaminophen-d3; Deuterated 3-Methoxy Paracetamol; 3-Methoxy APAP-d3; Acetaminophen 3-methyl ether-d3; 4'-Hydroxy-3'-methoxyacetanilide-d3; N-Acetyl-3-methoxy-p-aminophenol-d3
EINECS	Contact for details

Quality Control

Every batch of 3-Methoxy Acetaminophen-D3 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity. Our quality assurance protocols are designed to meet the stringent requirements of analytical reference standard applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for isotopic enrichment (D-content), chemical purity (by HPLC), and identity confirmation (by NMR and MS).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.