Description

Rac-Cotinine 3-Carboxylic Acid CAS NO 1246815-18-8 is a high-purity chemical intermediate of significant importance in advanced pharmaceutical research and development. This compound serves as a key chiral building block and analytical reference standard for the study of nicotine metabolites and related biochemical pathways. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in pharmacokinetic studies, biomarker analysis, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and validation of cotinine metabolites in bioanalytical methods.
• Metabolite Research: A critical intermediate in the study of nicotine metabolism, pharmacokinetics, and pharmacodynamics.
• Chiral Synthesis: Serves as a versatile building block for the synthesis of enantiomerically pure compounds in medicinal chemistry.
• Diagnostic Development: Employed in the development and calibration of diagnostic assays and kits for detecting tobacco use exposure.
• Biochemical Research: Used in enzymatic and receptor-binding studies to understand the biological fate of nicotine derivatives.
• Impurity Profiling: Acts as a known impurity or degradation product standard in the quality control of pharmaceutical products related to smoking cessation.

Basic Information

Product Name	Rac-Cotinine 3-Carboxylic Acid
CAS No.	1246815-18-8
Molecular Formula	C10H10N2O3
Molecular Weight	206.20 g/mol
Synonyms	Cotinine-3-carboxylic Acid (Racemic); DL-Cotinine-3-carboxylic Acid; 3-Carboxycotinine; 1-Methyl-5-(3-pyridyl)-2-pyrrolidinone-3-carboxylic Acid; N-Methyl-4-(3-pyridyl)-4-oxo-2-butanamide-3-carboxylic Acid; Nicotine Metabolite Carboxylic Acid (Racemic); (±)-Cotinine-3-carboxylic Acid; trans-3'-Hydroxycotinine Carboxylic Acid (Racemic)
EINECS	Contact for details

Quality Control

Our Rac-Cotinine 3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation by spectroscopic methods (IR, NMR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications requiring high levels of accuracy and reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Racemic mixture (50:50 ratio)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.