Description

Debrisoquin-13C,15N2 Hemisulfate is a stable isotope-labeled analog of the antihypertensive agent debrisoquin, specifically enriched with carbon-13 and nitrogen-15 isotopes. This compound is a critical internal standard for the precise quantification of debrisoquin in biological matrices using advanced analytical techniques like LC-MS/MS. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors, enabling accurate pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for Bioanalysis: Primary use as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the accurate measurement of debrisoquin in plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates studies on the absorption, distribution, metabolism, and excretion (ADME) of debrisoquin, a model compound for assessing cytochrome P450 2D6 (CYP2D6) enzyme activity.
• Clinical Research and Phenotyping: Used in clinical studies to determine an individual's CYP2D6 metabolizer status (e.g., poor, intermediate, extensive, ultra-rapid) for personalized medicine approaches.
• Pharmaceutical R&D: Supports method development and validation in pharmaceutical research for drugs metabolized by the CYP2D6 pathway.
• Forensic and Toxicology Testing: Enables precise and reliable quantification in forensic analysis and toxicological screenings.
• Reference Material Production: Serves as a certified reference material (CRM) or high-purity component for calibrators and controls in diagnostic kits.

Basic Information

Product Name	Debrisoquin-13C,15N2 Hemisulfate
CAS No.	1246814-89-0
Molecular Formula	C1613CH1915N2 • ½H2SO4
Molecular Weight	Contact for details
Synonyms	Debrisoquine-13C,15N2 Hemisulfate; 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide-13C,15N2 hemisulfate; (1,2,3,4-Tetrahydroisoquinolin-2-yl)guanidine-13C,15N2 sulfate (1:0.5); Declinax-13C,15N2; Isotopically Labeled Debrisoquin Hemisulfate; [13C,15N2]-Debrisoquin Hemisulfate; Stable Isotope-Labeled Debrisoquin Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Debrisoquin-13C,15N2 Hemisulfate is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, verified by advanced spectroscopic and chromatographic methods. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as assay (HPLC), isotopic purity (MS), and related substances. Our quality commitment ensures the reliability required for sensitive analytical applications in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥98.0% (on anhydrous basis)
Isotopic Purity	≥99 atom % 13C; ≥99 atom % 15N
Chemical Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.