Description

(R)-2-{[6-(3-Aminopiperidin-1-Yl)-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl]Methyl}Benzonitrile Hydrochloride is a high-purity, non-racemic chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its complex molecular architecture, which is critical for the synthesis of advanced active pharmaceutical ingredients (APIs) targeting specific biological pathways. This compound is primarily needed by pharmaceutical R&D organizations, contract research and manufacturing services (CRAMS) providers, and fine chemical suppliers engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of new chemical entities (NCEs), particularly for targeted therapies.
• API Synthesis: Serves as a critical precursor in the multi-step synthesis of complex, high-value active pharmaceutical ingredients.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot and commercial manufacturing scales.
• Biochemical Research: Potential use as a tool compound or probe for investigating enzyme inhibition and other biological mechanisms.
• Custom Synthesis: Sourced by companies requiring bespoke, high-purity chiral compounds for proprietary applications.

Basic Information

Product Name	(R)-2-{[6-(3-Aminopiperidin-1-Yl)-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl]Methyl}Benzonitrile Hydrochloride
CAS No.	1246610-75-2
Molecular Formula	C18H22N6O2 · HCl
Molecular Weight	390.87 g/mol (Free base: 354.41 g/mol)
Synonyms	(R)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile hydrochloride; (R)-2-{[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl}benzonitrile HCl; UNII-9K4G8B6R4I; 9K4G8B6R4I; (R)-enantiomer of a dihydropyrimidinone derivative; (R)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxopyrimidin-1(2H)-yl)methyl)benzonitrile hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-{[6-(3-Aminopiperidin-1-Yl)-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl]Methyl}Benzonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.