Description

1-(2-Bromoethynyl)-2-Fluorobenzene is a specialized halogenated aromatic building block featuring both bromoalkyne and fluoroaryl functional groups. This unique bifunctional structure makes it a highly valuable intermediate for advanced organic synthesis, particularly in constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, especially those requiring aryl-alkyne linkages.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate fluorinated aromatic systems.
• Material Science: Serves as a precursor for advanced polymers and liquid crystals, leveraging its rigid, halogenated structure.
• Cross-Coupling Reactions: An effective substrate in Sonogashira, Heck, and Suzuki-Miyaura couplings due to the reactive bromoalkyne moiety.
• Chemical Biology Probes: Utilized in the synthesis of fluorescent tags and molecular probes for bio-conjugation and imaging studies.
• Academic & Industrial R&D: A versatile building block for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	1-(2-Bromoethynyl)-2-Fluorobenzene
CAS No.	1246224-44-1
Molecular Formula	C8H4BrF
Molecular Weight	199.02 g/mol
Synonyms	2-Fluoro-1-(2-bromoethynyl)benzene; 1-Bromo-2-(2-fluorophenyl)ethyne; 2-Fluorophenyl Bromoacetylene; o-Fluorophenyl Bromoacetylene; (2-Bromoethynyl)-2-fluorobenzene; 2-Fluorobenzene, 1-(2-bromoethynyl)-; Bromo(2-fluorophenyl)acetylene
EINECS	Contact for details

Quality Control

Our 1-(2-Bromoethynyl)-2-Fluorobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.