Description

3-Fluoro-5-((Trimethylsilyl)ethynyl)picolinonitrile is a high-value, multi-functional organic building block featuring a unique combination of a picolinonitrile core, a fluorine substituent, and a trimethylsilyl-protected alkyne group. This compound is critically important for advanced research and development in medicinal chemistry and materials science, where its structure enables precise molecular modifications and the construction of complex architectures. It is primarily sought after by pharmaceutical R&D teams and specialty chemical manufacturers for applications in drug discovery, agrochemical development, and the synthesis of functional organic materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the discovery and synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Precursor: Acts as a monomer or building block for synthesizing advanced organic electronic materials, such as organic semiconductors and light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The protected alkyne moiety is ideal for Sonogashira and other palladium-catalyzed cross-coupling reactions to create conjugated molecular systems.
• Ligand Synthesis: Utilized in the preparation of novel nitrogen-containing ligands for catalysis and coordination chemistry.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in heterocyclic systems.

Basic Information

Product Name	3-Fluoro-5-((Trimethylsilyl)ethynyl)picolinonitrile
CAS No.	1246088-63-0
Molecular Formula	C11H11FN2Si
Molecular Weight	218.31 g/mol
Synonyms	3-Fluoro-5-((trimethylsilyl)ethynyl)pyridine-2-carbonitrile; 2-Cyano-3-fluoro-5-((trimethylsilyl)ethynyl)pyridine; 5-((Trimethylsilyl)ethynyl)-3-fluoropicolinonitrile; 3-Fluoro-5-(2-trimethylsilylethynyl)picolinonitrile; 3-Fluoro-5-(trimethylsilylethynyl)-2-pyridinecarbonitrile; 1246088-63-0; 3-Fluoro-5-[(trimethylsilyl)ethynyl]picolinonitrile
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-((Trimethylsilyl)ethynyl)picolinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.