Description

3-Fluoro-5-(3-Hydroxyprop-1-Yn-1-Yl)-Picolinonitrile is a high-value, multi-functional heterocyclic building block featuring a picolinonitrile core substituted with a fluoro group and a hydroxypropynyl side chain. This compound matters for its role as a critical intermediate in modern pharmaceutical and agrochemical research, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging its fluorine and nitrile motifs for bioactivity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science: Potential building block for organic electronic materials and liquid crystals due to its conjugated alkyne system and polar functional groups.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects and library production.

Basic Information

Product Name	3-Fluoro-5-(3-Hydroxyprop-1-Yn-1-Yl)-Picolinonitrile
CAS No.	1246088-46-9
Molecular Formula	C9H5FN2O
Molecular Weight	176.15 g/mol
Synonyms	3-Fluoro-5-(3-hydroxyprop-1-yn-1-yl)picolinonitrile; 5-(3-Hydroxy-1-propyn-1-yl)-3-fluoropicolinonitrile; 3-Fluoro-5-(3-hydroxypropynyl)-2-pyridinecarbonitrile; 2-Cyano-3-fluoro-5-(3-hydroxy-1-propynyl)pyridine; 3-Fluoro-5-(3-hydroxyprop-1-ynyl)picolinonitrile; Picolinonitrile, 3-fluoro-5-(3-hydroxy-1-propyn-1-yl)-
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(3-Hydroxyprop-1-Yn-1-Yl)-Picolinonitrile is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our commitment to quality supports your research and development needs with reliable, high-purity materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.