Description

5-Methyl-2-(Trifluoromethyl)Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethyl-substituted pyridine structure. This compound is of significant commercial importance due to its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring enhanced metabolic stability and bioavailability. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing next-generation small molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the trifluoromethyl group imparts desirable biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic materials and liquid crystals.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke chemical production.

Basic Information

Item	Detail
Product Name	5-Methyl-2-(Trifluoromethyl)Nicotinic Acid
CAS No.	1245915-92-7
Molecular Formula	C8H6F3NO2
Molecular Weight	205.14 g/mol
Synonyms	5-Methyl-2-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Carboxy-5-methyl-2-trifluoromethylpyridine; 2-Trifluoromethyl-5-methylnicotinic acid; 5-Methyl-2-trifluoromethylnicotinic acid; 1245915-92-7; 5-Methyl-2-(trifluoromethyl)-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-Methyl-2-(Trifluoromethyl)Nicotinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with client specifications and relevant industry guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.