Description

3-Formyl-5-(Trifluoromethyl)Phenol, also known as 3-Formyl-5-Hydroxybenzotrifluoride, is a high-value trifluoromethylated aromatic aldehyde building block prized for its unique combination of a reactive formyl group, a phenolic hydroxyl, and a stable trifluoromethyl moiety. This compound is essential for introducing fluorine-containing motifs into complex molecular architectures, which can dramatically alter physical, chemical, and biological properties. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, particularly those targeting CNS disorders, inflammation, and metabolic diseases, where the trifluoromethyl group enhances metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom to improve pesticidal activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Advanced Material Precursor: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials for enhanced performance and durability.
• Chemical Biology Probes: Utilized to develop fluorescent tags and molecular probes for studying biological processes.
• Custom Synthesis and R&D: A versatile starting material for contract research organizations (CROs) and fine chemical companies engaged in custom synthesis projects.

Basic Information

Product Name	3-Formyl-5-(Trifluoromethyl)Phenol
CAS No.	1243312-51-7
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	3-Formyl-5-Hydroxybenzotrifluoride; 5-(Trifluoromethyl)salicylaldehyde; 2-Hydroxy-5-(trifluoromethyl)benzaldehyde; 5-(Trifluoromethyl)-2-hydroxybenzaldehyde; 3-Hydroxy-5-(trifluoromethyl)benzaldehyde; 3-Formyl-5-(trifluoromethyl)phenol; 1243312-51-7; Benzaldehyde, 2-hydroxy-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-Formyl-5-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GLP and cGMP-compliant research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent oxidation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.