Description

8-Amino-6-Fluoro-3,4-Dihydro-2(1H)-Quinolinone (Saltdata: Free) is a high-purity, advanced pharmaceutical intermediate characterized by its unique quinolinone core structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for drug discovery and process development. The free base form offers greater flexibility for downstream chemical modifications in complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key building block for the research and synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging the biological activity of the fluorinated quinolinone structure.
• Chemical Synthesis Reference Standard: Serves as a high-purity standard for analytical method development and quality control in chemical production.
• Academic & R&D Laboratories: Employed in medicinal chemistry research for structure-activity relationship (SAR) studies and library synthesis.
• Precursor for Fluorinated Compounds: The presence of the fluorine atom makes it a valuable precursor for further fluorination chemistry and the creation of more complex fluorinated molecules.

Basic Information

Product Name	8-Amino-6-Fluoro-3,4-Dihydro-2(1H)-Quinolinone (Saltdata: Free)
CAS No.	1243250-06-7
Molecular Formula	C9H9FN2O
Molecular Weight	180.18 g/mol
Synonyms	8-Amino-6-fluoro-1,2,3,4-tetrahydroquinolin-2-one; 6-Fluoro-8-amino-3,4-dihydro-2(1H)-quinolinone; 2(1H)-Quinolinone, 8-amino-6-fluoro-3,4-dihydro-; 8-Amino-6-fluoro-1,2,3,4-tetrahydroquinolin-2-one (free base); 1243250-06-7 (CAS); 8-Amino-6-fluoro-3,4-dihydroquinolin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 8-Amino-6-Fluoro-3,4-Dihydro-2(1H)-Quinolinone (Saltdata: Free) is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.