Description

Wnt-C59 CAS NO 1243243-89-1 is a potent and selective small-molecule inhibitor of the Wnt signaling pathway, specifically targeting Porcupine (PORCN), a key enzyme in Wnt ligand palmitoylation and secretion. This targeted mechanism makes it an invaluable research tool for studying developmental biology, stem cell regulation, and oncogenesis. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and basic biological research.

Application

• Biomedical Research: Fundamental studies of Wnt/β-catenin signaling pathway dynamics and its role in cellular processes.
• Oncology Research: Investigation of Wnt-driven cancers (e.g., colorectal, breast) and evaluation of therapeutic strategies targeting this pathway.
• Stem Cell Research: Modulation of stem cell self-renewal, differentiation, and maintenance in both embryonic and adult stem cell models.
• Drug Discovery & Development: Used as a reference compound or pharmacological tool in high-throughput screening and lead optimization for novel PORCN or Wnt inhibitors.
• Developmental Biology: Research into tissue patterning, organogenesis, and regeneration where Wnt signaling plays a critical role.
• In Vitro & In Vivo Studies: Suitable for cell culture assays and animal model studies to elucidate Wnt pathway function in disease contexts.

Basic Information

Product Name	Wnt-C59
CAS No.	1243243-89-1
Molecular Formula	C₂₆H₂₃N₅O₃S
Molecular Weight	485.56 g/mol
Synonyms	C59; LGK974; (2S,3R)-N-(3-((2,3-Dihydro-1H-inden-4-yl)oxy)phenyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-3-carboxamide; PORCN Inhibitor C59; Wnt Inhibitor C59; Wnt Pathway Inhibitor C59; LGK-974; 2H-Pyrido[3,2-b]-1,4-oxazine-3-carboxamide, N-[3-[(2,3-dihydro-1H-inden-4-yl)oxy]phenyl]-2-methyl-4-oxo-, (2S,3R)-
EINECS	Contact for details

Quality Control

Our Wnt-C59 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay results, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.