Description

1-Chloro-5-Fluoro-2-Iodo-3-Methylbenzene is a high-purity, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and process chemists developing active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated benzene core.
• Material Science Precursor: Serves as a building block for organic electronic materials, liquid crystals, and advanced polymers where specific halogen atoms tune electronic properties.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for versatile palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig aminations.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.
• Ligand and Catalyst Development: Useful for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	1-Chloro-5-Fluoro-2-Iodo-3-Methylbenzene
CAS No.	1242339-79-2
Molecular Formula	C7H5ClFI
Molecular Weight	269.47 g/mol
Synonyms	3-Methyl-1-chloro-5-fluoro-2-iodobenzene; 2-Chloro-6-fluoro-3-iodotoluene; 1-Chloro-5-fluoro-2-iodo-3-methyl-benzene; 2-Iodo-6-fluoro-3-chlorotoluene; Toluene, 2-chloro-6-fluoro-3-iodo-; Benzene, 1-chloro-5-fluoro-2-iodo-3-methyl-; Halogenated Toluene Derivative
EINECS	Contact for details

Quality Control

Our 1-Chloro-5-Fluoro-2-Iodo-3-Methylbenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.