Description

2-Bromo-1-Chloro-5-Fluoro-3-Methylbenzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and process chemists developing active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the halogen pattern influences bioactivity.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and other functional materials requiring halogenated aromatic cores.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the presence of bromo and chloro leaving groups.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry to create diverse compound libraries for screening.
• Fluorine Chemistry: The fluorine substituent makes it valuable for studying structure-activity relationships (SAR) and improving metabolic stability in lead compounds.

Basic Information

Product Name	2-Bromo-1-Chloro-5-Fluoro-3-Methylbenzene
CAS No.	1242339-16-7
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-Bromo-2-Chloro-4-Fluoro-6-Methylbenzene; 3-Methyl-2-Bromo-1-Chloro-5-Fluorobenzene; 2-Bromo-1-Chloro-5-Fluoro-3-Methyl-Benzene; 2-Bromo-1-chloro-5-fluoro-3-methyl-benzene; Benzene, 2-bromo-1-chloro-5-fluoro-3-methyl-; 1242339-16-7; 2-Br-1-Cl-5-F-3-Me-Benzene
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-1-Chloro-5-Fluoro-3-Methylbenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (Area %)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residue on Ignition	<0.1%
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.