Description

4-Amino-6-Fluoronicotinic Acid is a high-purity, multi-functional heterocyclic building block of significant commercial interest. Its unique structure, featuring both amino and fluorine substituents on the pyridine ring, makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to create molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other synthetic transformations.
• Material Science Research: Employed in the development of organic electronic materials and functional dyes due to its electron-donating and accepting properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and contract research organizations (CROs/CMOs) serving the life sciences sector.

Basic Information

Product Name	4-Amino-6-Fluoronicotinic Acid
CAS No.	1242336-78-2
Molecular Formula	C6H5FN2O2
Molecular Weight	156.12 g/mol
Synonyms	6-Fluoro-4-aminonicotinic Acid; 4-Amino-6-fluoropyridine-3-carboxylic Acid; 3-Carboxy-6-fluoro-4-aminopyridine; 4-Amino-6-fluoro-3-pyridinecarboxylic Acid; 6-Fluoro-4-aminopyridine-3-carboxylic Acid; 4-Amino-6-fluoronicotinate; 1242336-78-2 (CAS)
EINECS	Contact for details

Quality Control

Our 4-Amino-6-Fluoronicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical and agrochemical applications. A comprehensive Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.