Description

5-Bromo-2-(2,2-difluoroethoxy)-3-methoxypyridine is a high-value, multi-functional pyridine derivative characterized by its bromine and difluoroethoxy substituents, making it a versatile building block for advanced chemical synthesis. This compound is engineered to serve as a critical intermediate in the development of complex molecules, particularly within the pharmaceutical and agrochemical sectors. It is essential for research chemists and process development scientists working on novel active ingredients, where its unique halogenated structure enables key coupling and functionalization reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoroethoxy group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a sophisticated building block for creating novel ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of advanced organic electronic materials, such as charge-transport layers or light-emitting components, due to its electron-deficient pyridine core.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	5-Bromo-2-(2,2-difluoroethoxy)-3-methoxypyridine
CAS No.	1241752-34-0
Molecular Formula	C8H8BrF2NO2
Molecular Weight	268.06 g/mol
Synonyms	3-Methoxy-5-bromo-2-(2,2-difluoroethoxy)pyridine; 2-(2,2-Difluoroethoxy)-3-methoxy-5-bromopyridine; 5-Bromo-3-methoxy-2-(2,2-difluoroethoxy)pyridine; 1241752-34-0; Pyridine, 5-bromo-2-(2,2-difluoroethoxy)-3-methoxy-
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(2,2-difluoroethoxy)-3-methoxypyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is sensitive to light (store away from light) and may be incompatible with strong alkalis and fluorides. Keep away from heat and ignition sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.