Description

4-Bromo-2-Fluoropyridine-3-Carboxylic Acid Methyl Ester is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its unique halogenated pyridine structure, which enables precise molecular modifications in complex chemical pathways. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, leveraging its halogenated pyridine core for bioactivity.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Chemical Library Development: Employed in combinatorial chemistry and high-throughput screening for lead discovery and optimization.
• Fluorinated Compound Synthesis: The fluorine atom provides a metabolic stability point for creating more stable and potent bioactive molecules.

Basic Information

Item	Details
Product Name	4-Bromo-2-Fluoropyridine-3-Carboxylic Acid Methyl Ester
CAS No.	1240611-45-3
Molecular Formula	C7H5BrFNO2
Molecular Weight	234.02 g/mol
Synonyms	Methyl 4-Bromo-2-fluoropyridine-3-carboxylate; 4-Bromo-2-fluoro-3-pyridinecarboxylic acid methyl ester; 3-Pyridinecarboxylic acid, 4-bromo-2-fluoro-, methyl ester; 4-Bromo-2-fluoronicotinic acid methyl ester; Methyl 4-bromo-2-fluoronicotinate
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoropyridine-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.