Description

Benzene, 1-(2-Bromo-2-Methylpropyl)-4-Fluoro- is a specialized halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, combining a fluorinated benzene ring with a reactive bromo-tert-butyl moiety, enabling precise chemical modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, such as active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used to develop novel herbicides and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for transition metal catalysis, leveraging the steric bulk of the bromo-tert-butyl group.
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination and cross-coupling reactions in academic and industrial R&D settings.
• Custom Synthesis Building Block: Provides a versatile handle for medicinal chemistry programs requiring the introduction of specific halogenated aromatic systems.

Basic Information

Product Name	Benzene, 1-(2-Bromo-2-Methylpropyl)-4-Fluoro-
CAS No.	1240520-37-9
Molecular Formula	C11H14BrF
Molecular Weight	245.13 g/mol
Synonyms	4-Fluoro-1-(2-bromo-2-methylpropyl)benzene; 1-(2-Bromo-2-methylpropyl)-4-fluorobenzene; 1-Bromo-2-(4-fluorophenyl)-2-methylpropane; p-Fluoro(2-bromo-2-methylpropyl)benzene; (2-Bromo-2-methylpropyl)-4-fluorobenzene; 4-Fluorobenzyl tert-butyl bromide (common name); α-Bromo-p-fluoro-tert-butylbenzene
EINECS	Contact for details

Quality Control

Our Benzene, 1-(2-Bromo-2-Methylpropyl)-4-Fluoro- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.