Description

n-Acetyl-D3-S-(3-Hydroxypropyl-1-Methyl)-L-Cysteine, Dicyclohexylammonium Salt is a high-purity, deuterated derivative of a key cysteine metabolite, specifically designed for advanced research and analytical applications. This compound is essential for use as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in biomarker analysis and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and analytical chemists focused on metabolomics, toxicology, and drug development.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of S-(3-hydroxypropyl-1-methyl)-L-cysteine and related mercapturic acid metabolites in biological matrices like urine and plasma.
• Biomarker Research: Enables accurate tracking of exposure to specific industrial chemicals or environmental toxins by serving as a reference in metabolic pathway studies.
• Pharmacokinetic/ADME Studies: Used in drug development to monitor the absorption, distribution, metabolism, and excretion of compounds metabolized through conjugation with glutathione.
• Clinical Toxicology: Supports the development and validation of diagnostic assays for monitoring human exposure to hazardous substances.
• Metabolomics Profiling: Aids in the discovery and validation of disease-specific metabolic signatures by providing a stable isotope-labeled reference point.
• Method Development & Validation: Serves as a crucial tool for developing robust, sensitive, and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	n-Acetyl-D3-S-(3-Hydroxypropyl-1-Methyl)-L-Cysteine, Dicyclohexylammonium Salt
CAS No.	1240483-48-0
Molecular Formula	C19H36D3N2O4S
Molecular Weight	~388.6 g/mol
Synonyms	Acetyl-D3-S-(3-hydroxypropyl-1-methyl)cysteine dicyclohexylammonium salt; N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine-d3 dicyclohexylamine salt; Deuterated HPMA-d3 mercapturate salt; D3-N-Acetyl-S-(3-hydroxypropyl-1-methyl)cysteine dicyclohexylammonium salt; Internal Standard for HPMA; HPMA-d3 metabolite standard; S-(3-Hydroxypropyl-1-methyl)-N-acetyl-L-cysteine-d3 dicyclohexylammonium salt; Stable Isotope Labeled Mercapturic Acid Salt
EINECS	Contact for details

Quality Control

Every batch of our n-Acetyl-D3-S-(3-Hydroxypropyl-1-Methyl)-L-Cysteine, Dicyclohexylammonium Salt is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. We provide comprehensive Certificates of Analysis (COA) detailing specifications for isotopic enrichment (D, %), chemical purity (by HPLC), and identity confirmation (by NMR and MS). Our quality commitment aligns with the standards expected for research-grade reference materials used in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.