Description

2-Methyl-5-(Pentafluorosulfur)Benzylbromide is a high-value organofluorine building block characterized by the presence of both a reactive benzyl bromide moiety and a pentafluorosulfanyl (SF5) group. This unique combination makes it a critical intermediate for the synthesis of advanced materials and bioactive compounds, offering enhanced lipophilicity, metabolic stability, and electronic properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases, where the SF5 group can improve bioavailability and binding affinity.
• Agrochemical Research: Used in creating advanced active ingredients for herbicides, fungicides, and insecticides, leveraging the SF5 group's ability to enhance pesticidal activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, where the SF5 substituent influences dielectric anisotropy and charge transport properties.
• Polymer & Coating Modifier: Incorporated into specialty polymers to impart unique surface characteristics, such as oil/water repellency (oleophobicity/hydrophobicity) and chemical resistance.
• Positron Emission Tomography (PET) Tracer Development: Potential use as a synthon for introducing fluorine-18 or other radioisotopes into tracer molecules for medical imaging.
• Ligand Synthesis for Catalysis: Employed in the preparation of sophisticated fluorinated ligands for transition metal catalysis, enabling new reaction pathways.

Basic Information

Product Name	2-Methyl-5-(Pentafluorosulfur)Benzylbromide
CAS No.	1240257-10-6
Molecular Formula	C8H6BrF5S
Molecular Weight	285.10 g/mol
Synonyms	1-(Bromomethyl)-2-methyl-5-(pentafluoro-λ6-sulfanyl)benzene; (5-(Bromomethyl)-2-methylphenyl)pentafluoro-λ6-sulfane; α-Bromo-2-methyl-5-(SF5)toluene; 2-Methyl-5-SF5-Benzyl Bromide; 5-(Bromomethyl)-2-methyl-1-(pentafluorosulfur)benzene
EINECS	Contact for details

Quality Control

Our 2-Methyl-5-(Pentafluorosulfur)Benzylbromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to support regulatory filings for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to minimize potential degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.