Description

tert-Butyl 4-Fluoropyridin-2-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine core with fluorine and carbamate functional groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced properties. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and agrochemical industries for the development of new therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging the fluorine atom for improved biological activity and metabolic stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and activity-based protein profiling (ABPP) reagents.
• Material Science Research: Employed in the synthesis of specialized ligands for catalysis and functional organic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	tert-Butyl 4-Fluoropyridin-2-Ylcarbamate
CAS No.	1237535-76-0
Molecular Formula	C10H13FN2O2
Molecular Weight	212.22 g/mol
Synonyms	tert-Butyl N-(4-Fluoropyridin-2-yl)carbamate; 2-Fluoro-4-((tert-butoxycarbonyl)amino)pyridine; 4-Fluoro-2-(((tert-butoxy)carbonyl)amino)pyridine; Boc-4-Fluoro-2-aminopyridine; N-Boc-4-Fluoro-2-aminopyridine; 2-Amino-4-fluoropyridine N-Boc derivative; Carbamic acid, N-(4-fluoro-2-pyridinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Fluoropyridin-2-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment. We adhere to relevant industry standards and can support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.