Description

1-Bromo-4-(3,3-Difluorocyclobutyl)Benzene is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorocyclobutyl aromatic structure. This compound is valued for its role as a versatile building block in modern synthetic chemistry, enabling the introduction of both halogen and fluorine-containing motifs. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly those targeting challenging biological pathways.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs for central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where the difluorocyclobutyl group can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for synthesizing specialty monomers and ligands used in advanced polymers and catalytic systems.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry: An important reagent for introducing the metabolically stable difluorocyclobutyl moiety into target molecules, a strategy used to optimize pharmacokinetic properties.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and scale-up projects for client molecules.

Basic Information

Product Name	1-Bromo-4-(3,3-Difluorocyclobutyl)Benzene
CAS No.	1236357-60-0
Molecular Formula	C10H9BrF2
Molecular Weight	247.08 g/mol
Synonyms	4-Bromo-1-(3,3-difluorocyclobutyl)benzene; 1-Bromo-4-(3,3-difluorocyclobut-1-yl)benzene; Benzene, 1-bromo-4-(3,3-difluorocyclobutyl)-; (3,3-Difluorocyclobutyl)benzene, 4-bromo-; p-Bromo(3,3-difluorocyclobutyl)benzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(3,3-Difluorocyclobutyl)Benzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports your regulatory filings and ensures reliable performance in your synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.