Description

Pi3Kα Inhibitor 1 is a potent and selective small molecule inhibitor of the phosphoinositide 3-kinase alpha (PI3Kα) isoform, a key signaling node in the PI3K/AKT/mTOR pathway. This compound is crucial for fundamental research into cellular proliferation, survival, and metabolism, and serves as a vital pharmacological tool for validating PI3Kα as a therapeutic target. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for drug discovery, target validation, and mechanistic studies in oncology and metabolic diseases.

Application

• Biochemical Research: Used as a selective probe to study the specific role of the PI3Kα isoform in cell signaling cascades.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design and optimization of novel PI3Kα-targeted therapeutics.
• Oncology Research: Employed in in vitro and in vivo studies to investigate tumor growth inhibition and potential combination therapies in cancers driven by PI3Kα mutations (e.g., breast, colorectal, gynecological).
• Target Validation: Essential for establishing the causal relationship between PI3Kα inhibition and observed phenotypic effects in disease models.
• Mechanistic Studies: Facilitates the understanding of downstream effectors in the PI3K pathway, such as AKT and mTOR.
• High-Throughput Screening (HTS): Can be used as a control compound in screening assays to identify new PI3Kα inhibitors.

Basic Information

Product Name	Pi3Kα Inhibitor 1
CAS No.	1235449-52-1
Molecular Formula	C21H21N5O3S
Molecular Weight	423.49 g/mol
Synonyms	GDC-0326; RG-7666; (S)-2-(1-(7-Methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethyl)-N-(5-methylpyrazin-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione; PI3K alpha Inhibitor 1; PI3Kα Inhibitor GDC-0326; PI3Kα Inhibitor RG-7666; PI3K-alpha Inhibitor 1
EINECS	Contact for details

Quality Control

Our Pi3Kα Inhibitor 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and NMR/LC-MS for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications for your records and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The product is stable under these conditions for at least two years from the date of receipt.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.