Description

2,4-Difluoro-5-Methylbenzenesulfonyl Chloride is a high-purity, multi-functional chemical intermediate essential for advanced organic synthesis. Its core value lies in its role as a versatile sulfonylation and sulfamoylation reagent, enabling the precise introduction of the sulfonyl chloride functional group into complex molecular architectures. This compound is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in the production of modern herbicides and fungicides, where the difluoro-methylbenzene scaffold contributes to bioactivity and metabolic stability.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Chemical Research: A valuable reagent in medicinal chemistry and process development for creating compound libraries and optimizing synthetic routes.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of specialized colorants and photographic chemicals.

Basic Information

Product Name	2,4-Difluoro-5-Methylbenzenesulfonyl Chloride
CAS No.	1235407-51-8
Molecular Formula	C7H5ClF2O2S
Molecular Weight	226.63 g/mol
Synonyms	5-Methyl-2,4-difluorobenzenesulfonyl chloride; 2,4-Difluoro-5-methylbenzene-1-sulfonyl chloride; 2,4-Difluoro-5-methylphenylsulfonyl chloride; 1-(Chlorosulfonyl)-2,4-difluoro-5-methylbenzene; Benzenesulfonyl chloride, 2,4-difluoro-5-methyl-; 5-Methyl-2,4-difluorophenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-5-Methylbenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.