Description

Trans (15S)-Latanoprost is a stereoisomerically pure form of the prostaglandin F2α analog, Latanoprost. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis of advanced ophthalmic agents. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on developing and producing innovative glaucoma treatments and other prostaglandin-based therapeutics.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral building block in the synthesis of Latanoprost and related prostaglandin analogs.
• Ophthalmic Drug Development: Research and production of medications for reducing intraocular pressure in patients with open-angle glaucoma and ocular hypertension.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and commercial-scale manufacturing processes for prostaglandin-based drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Biochemical Research: Investigation of prostaglandin receptor activity, signaling pathways, and structure-activity relationships (SAR).
• Custom Synthesis: A starting material for the preparation of novel prostaglandin derivatives and prodrugs for therapeutic evaluation.

Basic Information

Product Name	Trans (15S)-Latanoprost
CAS No.	1235141-39-5
Molecular Formula	C26H40O5
Molecular Weight	432.60 g/mol
Synonyms	(15S)-Latanoprost; (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester; Latanoprost Impurity; Latanoprost Related Compound; Prostaglandin F2α analog; Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoate; 9-Ketoprostaglandin F1α analog
EINECS	Contact for details

Quality Control

Our Trans (15S)-Latanoprost is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assays, to ensure it meets stringent specifications for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development and regulatory requirements with materials suitable for use under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at controlled room temperature (15-25°C) or as specified on the label. Due to its sensitivity to oxidation, the container should be sealed immediately after use to minimize exposure to air.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.