Description

Lalistat 2 is a potent and selective inhibitor of lysosomal acid lipase (LAL), a key enzyme in cholesterol ester metabolism. This compound is a critical research tool for studying lipid storage disorders, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). It is essential for pharmaceutical R&D, academic research, and diagnostic development in the fields of metabolic and cardiovascular disease.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of lysosomal acid lipase in cellular cholesterol homeostasis and lipid droplet formation.
• Drug Discovery: Serves as a reference compound and pharmacological tool in high-throughput screening assays for developing novel LAL-targeting therapeutics.
• Disease Modeling: Employed in vitro and in vivo to create models of lysosomal acid lipase deficiency (LAL-D), such as Wolman disease and cholesteryl ester storage disease (CESD).
• Mechanistic Studies: Facilitates investigation into lipid metabolism pathways, autophagy, and inflammation associated with metabolic syndrome.
• Diagnostic Development: Acts as a control inhibitor in enzymatic activity assays for the clinical diagnosis of LAL-D.

Basic Information

Product Name	Lalistat 2
CAS No.	1234569-09-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	LAL Inhibitor 2; LAListat 2; Lysosomal Acid Lipase Inhibitor 2; (3S,4aR,6aR,6bS,8aR,9S,10S,12aR,12bR,14bS)-3,6a,6b,9,12a-Pentamethyl-10-((4-methylpiperazin-1-yl)methyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid (IUPAC); LALi-2
EINECS	Contact for details

Quality Control

Our Lalistat 2 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.