Description

Lrrk2-In-1 CAS NO 1234480-84-2 is a potent and selective small-molecule inhibitor targeting the leucine-rich repeat kinase 2 (LRRK2), a key protein implicated in Parkinson's disease pathology. This high-purity research chemical is essential for advancing neurological studies, offering a critical tool for investigating LRRK2 kinase activity and its role in cellular pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neurodegenerative disease therapeutics and kinase biology.

Application

• Parkinson's Disease Research: A key pharmacological tool for in vitro and in vivo studies investigating LRRK2's role in disease mechanisms.
• Kinase Profiling & Selectivity Assays: Used to assess the specificity of LRRK2-In-1 against a panel of kinases to understand off-target effects.
• Cell-Based Functional Studies: Enables the study of LRRK2-mediated cellular processes, such as autophagy, lysosomal function, and neurite outgrowth.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in screening campaigns for novel LRRK2 inhibitors.
• Preclinical Drug Development: Supports lead optimization and pharmacokinetic/pharmacodynamic (PK/PD) studies for potential Parkinson's disease therapeutics.
• Biochemical Pathway Analysis: Facilitates the dissection of signaling pathways upstream and downstream of LRRK2 kinase activity.

Basic Information

Product Name	Lrrk2-In-1
CAS No.	1234480-84-2
Molecular Formula	C₂₆H₃₀N₈O₂
Molecular Weight	486.57 g/mol
Synonyms	LRRK2-IN-1; LRRK2 Inhibitor 1; 4-(4-(3-(2-(Trifluoromethyl)-9H-purin-6-yl)amino)piperidin-1-yl)methyl)piperidin-1-yl)benzonitrile; GNE-7915; GNE7915; 2-(Trifluoromethyl)-9H-purin-6-amine derivative; LRRK2 kinase inhibitor
EINECS	Contact for details

Quality Control

Our Lrrk2-In-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and NMR/LC-MS for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.