Description

2-Ethynyl-6-Fluoropyridine is a high-value, multi-functional heterocyclic building block featuring both a fluorine substituent and an ethynyl group. This unique structure makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, ligand synthesis, and the creation of novel polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, conductive materials, and metal-organic frameworks (MOFs).
• Ligand in Catalysis: The pyridine nitrogen and ethynyl group allow for the creation of sophisticated ligands used in transition metal catalysis for asymmetric synthesis.
• Chemical Biology Probe: Utilized in click chemistry applications via the alkyne group for bioconjugation and labeling of biomolecules.
• Organic Electronic Materials: A component in the research of organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs) due to its electron-deficient aromatic system.

Basic Information

Product Name	2-Ethynyl-6-Fluoropyridine
CAS No.	1233205-73-6
Molecular Formula	C7H4FN
Molecular Weight	121.11 g/mol
Synonyms	6-Fluoro-2-ethynylpyridine; 2-Ethynyl-6-fluoropyridine; 6-Fluoro-2-pyridylacetylene; 2-Fluoro-6-ethynylpyridine; 2-Ethynyl-6-fluoro-pyridine; 6-Fluoropyridin-2-ylacetylene; (6-Fluoropyridin-2-yl)ethyne
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-6-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent quality suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.