Description

4-Chloro-2-Fluoronicotinaldehyde is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique halogenated structure makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluoropyridine moiety enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized organic materials, including liquid crystals and organic semiconductors.
• Custom Chemical Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	4-Chloro-2-Fluoronicotinaldehyde
CAS No.	1232432-20-0
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	2-Fluoro-4-chloropyridine-5-carbaldehyde; 5-Formyl-4-chloro-2-fluoropyridine; 4-Chloro-2-fluoro-5-pyridinecarboxaldehyde; 4-Chloro-2-fluoropyridine-5-carbaldehyde; 2-Fluoro-4-chloro-5-formylpyridine; 4-Chloro-2-fluoro-3-pyridinecarboxaldehyde; Nicotinaldehyde, 4-chloro-2-fluoro-
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-2-Fluoronicotinaldehyde adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.