Description

2-(Bromomethyl)-1-Fluoro-3-Iodobenzene, also known as α-Bromo-2-Fluoro-6-Iodotoluene, is a high-value, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromomethyl, fluoro, and iodo substituents on a benzene ring, makes it a versatile and reactive intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions, nucleophilic substitutions, and as a precursor to novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new small-molecule drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the introduction of halogenated aromatic systems is critical for bioactivity.
• Material Science Precursor: Serves as a building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials that require precise halogen functionalization.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed reactions (e.g., Suzuki, Stille, Negishi) due to the presence of both bromine and iodine leaving groups, allowing for sequential functionalization.
• Nucleophilic Substitution: The reactive bromomethyl group facilitates further derivatization through reactions with various nucleophiles, enabling side-chain elongation and diversification.
• Chemical Research & Development: An essential tool in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities for screening.

Basic Information

Product Name	2-(Bromomethyl)-1-Fluoro-3-Iodobenzene, α-Bromo-2-Fluoro-6-Iodotoluene
CAS No.	1231747-49-1
Molecular Formula	C7H5BrFI
Molecular Weight	314.92 g/mol
Synonyms	2-(Bromomethyl)-1-fluoro-3-iodobenzene; 1-Fluoro-3-iodo-2-(bromomethyl)benzene; α-Bromo-2-fluoro-6-iodotoluene; 2-Fluoro-6-iodobenzyl bromide; (2-Fluoro-6-iodophenyl)methyl bromide; Benzene, 2-(bromomethyl)-1-fluoro-3-iodo-; Bromomethyl-fluoro-iodobenzene
EINECS	Contact for details

Quality Control

Our production of 2-(Bromomethyl)-1-Fluoro-3-Iodobenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support cGMP and ISO-aligned standards for advanced intermediates, and specifications can be customized to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to minimize potential degradation. Handle and store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.