Description

4-Ethynyl-2-Fluoropyridine is a high-value, multi-functional heterocyclic building block featuring both a fluoropyridine core and a terminal alkyne group. This unique molecular architecture makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, ligand synthesis, and the creation of novel polymers.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the bioactivity of the fluoropyridine moiety.
• Material Science Building Block: Employed in the synthesis of conductive polymers, metal-organic frameworks (MOFs), and advanced organic electronic materials via its ethynyl group.
• Click Chemistry Reagent: The terminal alkyne enables efficient Huisgen 1,3-dipolar cycloaddition (click chemistry) for bioconjugation and polymer functionalization.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in homogeneous catalysis and organometallic chemistry.
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	4-Ethynyl-2-Fluoropyridine
CAS No.	1231192-86-1
Molecular Formula	C7H4FN
Molecular Weight	121.11 g/mol
Synonyms	2-Fluoro-4-ethynylpyridine; 4-Ethynyl-2-fluoropyridine; 2-Fluoro-4-ethynylpyridine; 4-Ethynyl-2-fluoro-pyridine; Pyridine, 4-ethynyl-2-fluoro-; 2-Fluoro-4-(ethynyl)pyridine
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-2-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.