Description

Mps1-In-2 CAS NO 1228817-38-6 is a potent and selective small-molecule inhibitor of the monopolar spindle 1 (MPS1/TTK) kinase, a key regulator of the spindle assembly checkpoint. This compound is a critical research tool for studying cell cycle dynamics, mitotic fidelity, and chromosomal instability in oncology and cell biology research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cancer therapeutics and fundamental cellular mechanisms.

Application

• Cancer Research & Drug Discovery: Used as a reference standard and pharmacological probe to investigate the role of MPS1 kinase in tumorigenesis and to validate novel therapeutic targets.
• Cell Biology Studies: Essential for in vitro and cellular assays to dissect the spindle assembly checkpoint (SAC), mitotic progression, and aneuploidy.
• Biochemical Screening: Serves as a control compound in high-throughput screening (HTS) campaigns to identify new MPS1 inhibitors or modulators.
• Preclinical Development: Supports proof-of-concept studies in animal models to evaluate the antitumor efficacy of targeting MPS1.
• Mechanism of Action (MoA) Studies: Employed to understand resistance mechanisms and synergistic drug combinations in cancer cell lines.

Basic Information

Product Name	Mps1-In-2
CAS No.	1228817-38-6
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	MPS1-IN-2; TTK Inhibitor Mps1-In-2; 2-[[4-[(4-Methyl-1-piperazinyl)methyl]phenyl]amino]-5H-pyrimido[5,4-b]indol-4-amine; NMS-P715 (Analog); MPS1/TTK Kinase Inhibitor; Monopolar Spindle 1 Inhibitor II
EINECS	Contact for details

Quality Control

Our Mps1-In-2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.