Description

5-Fluoro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]-Pyridine-4-Carbonitrile is a high-value, advanced pharmaceutical intermediate featuring a fused pyrrolopyridine core protected by a triisopropylsilyl (TIPS) group. This compound is specifically engineered for use in the synthesis of complex active pharmaceutical ingredients (APIs), where its unique structure serves as a critical building block. It is essential for research and development chemists and manufacturers in the pharmaceutical and agrochemical industries, particularly those focused on kinase inhibitors and other nitrogen-containing heterocyclic therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors.
• Agrochemical Research: Used in the development of new pesticides and herbicides that require fluorinated heterocyclic scaffolds.
• Chemical Biology Probes: Serves as a versatile scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science: Potential building block for organic electronic materials due to its conjugated π-system and functional handles.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clients.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	5-Fluoro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]-Pyridine-4-Carbonitrile
CAS No.	1228666-58-7
Molecular Formula	C19H28FN3Si
Molecular Weight	345.53 g/mol
Synonyms	4-Cyano-5-fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 5-fluoro-1-(triisopropylsilyl)-; 5-Fluoro-1-TIPS-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile; TIPS-Protected 5-Fluoropyrrolopyridine-4-carbonitrile; 1228666-58-7; 5-Fluoro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]-Pyridine-4-Carbonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.