Description

3-(2-Fluoro-6-(Pyrrolidin-1-Yl)Pyridin-3-Yl)-Prop-2-Yn-1-Ol is a high-value, fluorinated pyridine derivative featuring a pyrrolidine substituent and a propargylic alcohol functional group. This unique molecular architecture makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block for medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical sectors. The compound's structure is designed to enable the synthesis of novel bioactive molecules targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Medicinal Chemistry Research: Used as a sophisticated building block for constructing compound libraries in drug discovery programs, leveraging its fluorine atom and alkyne moiety for structure-activity relationship (SAR) studies.
• Agrochemical Development: Acts as an intermediate in the research and synthesis of novel herbicides, fungicides, or insecticides, where the fluoropyridine core is a common bioactive motif.
• Chemical Biology Probes: The alkyne handle allows for bioorthogonal "click chemistry" applications, enabling the labeling and study of biological targets.
• Material Science Research: Potential use as a monomer or functional additive in the development of specialty polymers and advanced organic materials.

Basic Information

Product Name	3-(2-Fluoro-6-(Pyrrolidin-1-Yl)Pyridin-3-Yl)-Prop-2-Yn-1-Ol
CAS No.	1228666-51-0
Molecular Formula	C12H13FN2O
Molecular Weight	220.24 g/mol
Synonyms	2-Fluoro-6-(pyrrolidin-1-yl)-3-(2-propyn-1-yloxy)pyridine; 3-(2-Fluoro-6-(1-pyrrolidinyl)-3-pyridinyl)-2-propyn-1-ol; 1-(3-Fluoro-5-(3-hydroxyprop-1-yn-1-yl)pyridin-2-yl)pyrrolidine; 2-Fluoro-6-(pyrrolidin-1-yl)pyridin-3-yl propargyl ether; Propargyl 2-fluoro-6-(pyrrolidin-1-yl)pyridin-3-yl ether; 1228666-51-0; FC-1063 (Potential Research Code)
EINECS	Contact for details

Quality Control

We maintain a strict quality management system to ensure batch-to-batch consistency and high purity for research and development applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.