Description

2-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-6-Fluoropyridine is a high-value, organosilicon-protected pyrrolidine derivative that serves as a critical synthetic intermediate in modern pharmaceutical research and development. Its molecular architecture, featuring a fluoropyridine moiety and a tert-butyldimethylsilyl (TBDMS) protected hydroxymethyl group, makes it an essential building block for constructing complex bioactive molecules. This compound is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce fluoropyridine and protected pyrrolidine motifs.
• Process Chemistry Development: Serves as a standardized intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Agrochemical Synthesis: Intermediate in the development of advanced pesticides and herbicides where the fluoropyridine unit enhances biological activity.
• Ligand and Catalyst Preparation: Precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for proprietary client projects.

Basic Information

Product Name	2-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-6-Fluoropyridine
CAS No.	1228666-47-4
Molecular Formula	C16H27FN2OSi
Molecular Weight	310.49 g/mol
Synonyms	6-Fluoro-2-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]pyridine; 2-(3-((TBDMSO)Methyl)-Pyrrolidin-1-Yl)-6-Fluoropyridine; 1-(6-Fluoropyridin-2-yl)-3-((tert-butyldimethylsilyloxy)methyl)pyrrolidine; TBDMS-protected 3-(hydroxymethyl)pyrrolidine fluoropyridine derivative; 6-Fluoro-2-(3-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)pyridine; 1228666-47-4; Fluoropyridine pyrrolidine silyl ether
EINECS	Contact for details

Quality Control

Every batch of 2-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-6-Fluoropyridine is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the exacting standards of pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Keep the container tightly sealed in a desiccator after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.