Description

3-(2-Amino-5-Fluoropyridin-3-Yl)Prop-2-Yn-1-Ol is a high-purity, functionalized pyridine derivative featuring both an amino and a fluorinated aromatic ring, connected by a propargylic alcohol linker. This unique molecular architecture makes it a critical building block for medicinal chemistry and advanced material synthesis, enabling the rapid construction of complex molecular scaffolds. It is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Chemical Biology Probe Development: The alkyne handle allows for efficient conjugation via click chemistry, making it valuable for creating molecular probes and diagnostic agents.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced organic frameworks.
• Academic & Contract Research: Essential for synthetic chemistry research in universities and CROs (Contract Research Organizations) exploring new heterocyclic compounds.

Basic Information

Product Name	3-(2-Amino-5-Fluoropyridin-3-Yl)Prop-2-Yn-1-Ol
CAS No.	1228666-34-9
Molecular Formula	C8H7FN2O
Molecular Weight	166.15 g/mol
Synonyms	3-(2-Amino-5-fluoropyridin-3-yl)prop-2-yn-1-ol; 2-Amino-5-fluoro-3-(2-propyn-1-ol)pyridine; 5-Fluoro-3-(2-propynyloxy)-2-pyridinamine; 2-Amino-3-(3-hydroxy-1-propynyl)-5-fluoropyridine; 3-(2-Amino-5-fluoropyridin-3-yl)-2-propyn-1-ol; Propargyl alcohol, 3-(2-amino-5-fluoropyridin-3-yl)-; CAS 1228666-34-9
EINECS	Contact for details

Quality Control

Every batch of 3-(2-Amino-5-Fluoropyridin-3-Yl)Prop-2-Yn-1-Ol is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.