Description

n-(5-Fluoro-3-(3-Hydroxypropyl)Pyridin-2-Yl)-Pivalamide is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its precise molecular structure, which serves as a critical building block in modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and commercial production of targeted small-molecule drugs.
• Oncology Research: Used in the development of potential anti-cancer compounds due to its fluorinated pyridine core structure.
• CNS Drug Discovery: Serves as a building block for novel neuroactive compounds targeting specific receptors.
• Process Chemistry & Scale-up: Employed in route scouting, optimization, and pilot-scale synthesis for new chemical entities (NCEs).
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP-compliant API synthesis.
• Academic & Institutional Research: Used in university and institutional labs for medicinal chemistry studies and biological screening.

Basic Information

Product Name	n-(5-Fluoro-3-(3-Hydroxypropyl)Pyridin-2-Yl)-Pivalamide
CAS No.	1228665-80-2
Molecular Formula	C13H19FN2O2
Molecular Weight	254.30 g/mol
Synonyms	Pivalamide, N-[5-fluoro-3-(3-hydroxypropyl)-2-pyridinyl]-; 2-Pyridineacetamide, 5-fluoro-3-(3-hydroxypropyl)-N-(2,2-dimethyl-1-oxopropyl)-; 1228665-80-2; 5-Fluoro-3-(3-hydroxypropyl)-N-pivaloylpyridin-2-amine; N-(5-Fluoro-3-(3-hydroxypropyl)pyridin-2-yl)-2,2-dimethylpropanamide
EINECS	Contact for details

Quality Control

Our n-(5-Fluoro-3-(3-Hydroxypropyl)Pyridin-2-Yl)-Pivalamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.