Description

1-(2-Fluoro-6-(Pyrrolidin-1-Yl)Pyridin-4-Yl)-Ethanone is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique molecular scaffold, which combines a fluorine substituent and a pyrrolidine moiety to modulate the reactivity and physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine-tuning drug candidate properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Research: Used in developing new herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Chemical Biology Probe Development: Serves as a core structure for creating molecular probes to study enzyme function and biological pathways.
• Material Science: Employed in the synthesis of specialty chemicals and advanced materials, including liquid crystals and organic semiconductors.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring complex, fluorinated heterocycles.

Basic Information

Product Name	1-(2-Fluoro-6-(Pyrrolidin-1-Yl)Pyridin-4-Yl)-Ethanone
CAS No.	1228665-59-5
Molecular Formula	C11H13FN2O
Molecular Weight	208.23 g/mol
Synonyms	1-[2-Fluoro-6-(pyrrolidin-1-yl)pyridin-4-yl]ethanone; 2-Fluoro-6-(pyrrolidin-1-yl)isonicotinophenone; 4-Acetyl-2-fluoro-6-(1-pyrrolidinyl)pyridine; 1-(2-Fluoro-6-(1-pyrrolidinyl)-4-pyridinyl)ethanone; 1-(2-Fluoro-6-(pyrrolidin-1-yl)-4-pyridinyl)ethan-1-one; CAS 1228665-59-5
EINECS	Contact for details

Quality Control

Our 1-(2-Fluoro-6-(Pyrrolidin-1-Yl)Pyridin-4-Yl)-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.