Description

Cinacalcet CAS NO 1228567-12-1 is a potent and selective calcimimetic agent that acts as an allosteric modulator of the calcium-sensing receptor (CaSR). This compound is of critical importance in the pharmaceutical industry for the development of treatments for secondary hyperparathyroidism and hypercalcemia. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the synthesis of active pharmaceutical ingredients (APIs) for end-stage renal disease and parathyroid carcinoma therapies.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the manufacture of finished dosage forms for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis.
• Research Chemical: Essential tool in pharmacological and biochemical research for studying calcium homeostasis and the function of the calcium-sensing receptor pathway.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.
• Process Development: Used in process chemistry for the scale-up and optimization of synthetic routes for calcimimetic agents.
• Formulation Studies: Employed in pre-formulation and formulation development to study stability, excipient compatibility, and bioavailability.

Basic Information

Product Name	Cinacalcet
CAS No.	1228567-12-1
Molecular Formula	C22H22F3N
Molecular Weight	357.42 g/mol
Synonyms	N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine; Cinacalcet Hydrochloride (salt form); AMG 073; Sensipar (Brand Name); Mimpara (Brand Name); (R)-N-[1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine; Calcimimetic Cinacalcet
EINECS	Contact for details

Quality Control

Our Cinacalcet is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.