Description

1,4-Dioxane-13C4 is a stable isotope-labeled analog of 1,4-dioxane, where all four carbon atoms are replaced with the carbon-13 (13C) isotope. This compound is an essential internal standard and tracer in advanced analytical chemistry, enabling precise quantification and metabolic pathway elucidation. It is primarily required by research laboratories, pharmaceutical developers, and environmental testing facilities engaged in mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, and pharmacokinetic studies.

Application

• Quantitative Analytical Standard: Serves as a critical internal standard for the accurate Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS) analysis of unlabeled 1,4-dioxane in environmental, pharmaceutical, and consumer product samples.
• Metabolic Research & Tracing: Used as a stable isotope tracer in biomedical and toxicological research to study the absorption, distribution, metabolism, and excretion (ADME) of 1,4-dioxane in biological systems.
• NMR Spectroscopy Solvent & Reference: Employed as a 13C-enriched solvent or chemical shift reference compound in complex NMR experiments for structural analysis and dynamics studies.
• Method Development & Validation: Essential for developing and validating highly sensitive and specific analytical methods in compliance with regulatory guidelines for impurity detection.
• Quality Control in Manufacturing: Used in the quality assurance labs of chemical and pharmaceutical manufacturers to monitor and control potential 1,4-dioxane impurities in solvents and final products.
• Environmental Forensics: Aids in source identification and fate-transport studies of 1,4-dioxane contamination in groundwater and soil.

Basic Information

Product Name	1,4-Dioxane-13C4
CAS No.	1228182-37-3
Molecular Formula	13C4H8O2
Molecular Weight	92.08 g/mol (approx.)
Synonyms	1,4-Dioxane-13C4; [13C4]-1,4-Dioxane; p-Dioxane-13C4; Diethylene dioxide-13C4; 1,4-Diethylene dioxide-13C4; Dioxane-13C4; Isotope-labeled 1,4-dioxane; 13C4-1,4-Dioxane
EINECS	Contact for details

Quality Control

Every batch of 1,4-Dioxane-13C4 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing via NMR, GC-MS, and IR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting batch-specific data on assay, isotopic enrichment, and impurity profiles to ensure it meets your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed and stored upright away from heat and ignition sources.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms to structure
Isotopic Enrichment	≥ 99 atom % 13C
Assay (GC)	≥ 99.0% (on anhydrous basis)
Water Content (KF)	≤ 0.1%
1H NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.