Description

4-{[4-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Benzenesulfonyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive sulfonyl chloride group and trifluoromethylpyridine moiety. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific bioisosteric properties. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of sulfonamide-based drug candidates, leveraging its reactive site for coupling with amines.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique surface properties.
• Chemical Biology Probes: Employed in the creation of activity-based probes for studying enzyme function and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	4-{[4-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Benzenesulfonyl Chloride
CAS No.	1227955-11-4
Molecular Formula	C12H7ClF3NO3S
Molecular Weight	337.70 g/mol
Synonyms	2-[(4-Chlorosulfonyl)phenoxy]-4-(trifluoromethyl)pyridine; 4-((4-(Trifluoromethyl)pyridin-2-yl)oxy)benzenesulfonyl chloride; Benzenesulfonyl chloride, 4-[[4-(trifluoromethyl)-2-pyridinyl]oxy]-; 4-(4-Trifluoromethylpyridin-2-yloxy)benzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-{[4-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Benzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.