Description

Stemregenin 1 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist widely recognized for its critical role in stem cell research and expansion. This small molecule is essential for enhancing the ex vivo proliferation of hematopoietic stem cells (HSCs) without inducing differentiation, a key challenge in cell therapy and regenerative medicine. It is a fundamental research tool for scientists and manufacturers in the biotechnology, pharmaceutical, and advanced therapeutic medicinal product (ATMP) sectors, enabling breakthroughs in cell-based therapies and drug discovery.

Application

• Hematopoietic Stem Cell (HSC) Expansion: Primary application for enhancing the yield of CD34+ cells in ex vivo culture systems for transplantation and research.
• Cell Therapy Manufacturing: Critical component in protocols for generating sufficient quantities of therapeutic cells for clinical applications.
• Regenerative Medicine Research: Used to study stem cell self-renewal, maintenance of pluripotency, and mechanisms of the AhR signaling pathway.
• Drug Discovery & Toxicology: Serves as a pharmacological tool to investigate AhR-mediated processes and screen for modulators of this receptor.
• Biobanking and Cell Banking: Improves the recovery and viability of stem cells after cryopreservation and thawing.
• Academic and Institutional Research: A standard reagent in laboratories focused on immunology, oncology, and developmental biology.

Basic Information

Product Name	Stemregenin 1
CAS No.	1227633-49-9
Molecular Formula	C₂₀H₁₅N₃O₂
Molecular Weight	329.35 g/mol
Synonyms	SR1; StemRegenin 1; 4-(2-(2-(Benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-ylamino)ethyl)phenol; AHR antagonist SR-1; AhR Inhibitor SR1
EINECS	Contact for details

Quality Control

Every batch of Stemregenin 1 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and potency for research use. We provide full traceability and Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay purity and impurity profiles. Our quality standards are designed to support reproducible and reliable scientific outcomes in sensitive cell culture applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. For long-term storage, consider desiccation. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.