Description

2-Chloromethyl-3-Hydroxy-6-(Trifluoromethyl)Pyridine is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring both a reactive chloromethyl group and a trifluoromethyl substituent, makes it an indispensable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used to construct advanced pyridine-based herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and functional materials, where the pyridine core contributes to electronic or binding properties.
• Chemical Biology Probes: Utilized to synthesize molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	2-Chloromethyl-3-Hydroxy-6-(Trifluoromethyl)Pyridine
CAS No.	1227606-43-0
Molecular Formula	C8H5ClF3NO
Molecular Weight	223.58 g/mol
Synonyms	3-Hydroxy-6-(trifluoromethyl)-2-pyridinemethanol, chloride; 2-(Chloromethyl)-3-hydroxy-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-3-pyridinol, 2-(chloromethyl)-; 2-Pyridinemethanol, 3-hydroxy-6-(trifluoromethyl)-, chloride; 1227606-43-0
EINECS	Contact for details

Quality Control

Every batch of 2-Chloromethyl-3-Hydroxy-6-(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and scale-up activities. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.