Description

2,5-Difluoropyridine-3-Carboxaldehyde is a versatile fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and an aldehyde functional group, enabling precise molecular modifications for creating high-value compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science sectors, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, where the difluoropyridine moiety enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Precursor: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized to create fluorinated probes and tags for studying biological systems and mechanisms.
• Custom Synthesis and R&D: A valuable starting material for contract research organizations (CROs) and fine chemical companies engaged in custom synthesis projects.

Basic Information

Product Name	2,5-Difluoropyridine-3-Carboxaldehyde
CAS No.	1227602-25-6
Molecular Formula	C6H3F2NO
Molecular Weight	143.09 g/mol
Synonyms	3-Formyl-2,5-difluoropyridine; 2,5-Difluoropyridine-3-carbaldehyde; 2,5-Difluoro-3-pyridinecarboxaldehyde; 3-Pyridinecarboxaldehyde, 2,5-difluoro-; 1227602-25-6; 2,5-Difluoro-3-formylpyridine
EINECS	Contact for details

Quality Control

Our 2,5-Difluoropyridine-3-Carboxaldehyde is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.