Description

(5,6-Difluoropyridin-2-Yl)Methanol is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique difluoropyridine scaffold, which is essential for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily needed by pharmaceutical and agrochemical R&D sectors for the development of novel active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and asymmetric synthesis.
• Material Science Precursor: Intermediate in the synthesis of fluorinated liquid crystals, organic semiconductors, and advanced polymers.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a molecular probe.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(5,6-Difluoropyridin-2-Yl)Methanol
CAS No.	1227601-43-5
Molecular Formula	C6H5F2NO
Molecular Weight	145.11 g/mol
Synonyms	2-(Hydroxymethyl)-5,6-difluoropyridine; 5,6-Difluoro-2-pyridinemethanol; (5,6-Difluoro-2-pyridinyl)methanol; 5,6-Difluoropyridine-2-methanol; 2-Pyridinemethanol, 5,6-difluoro-; (5,6-Difluoropyridin-2-yl)methanol; Difluoropyridinemethanol
EINECS	Contact for details

Quality Control

Our (5,6-Difluoropyridin-2-Yl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting our commitment to supply reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.