Description

6-Chloro-2-Fluoropyridin-3-Amine is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce halogen and amine functionalities into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A versatile synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials and functional polymers.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) facilities.
• Academic & Industrial R&D: Essential for exploratory chemistry in academic institutions and corporate R&D centers focused on heterocyclic chemistry.

Basic Information

Product Name	6-Chloro-2-Fluoropyridin-3-Amine
CAS No.	1227600-05-6
Molecular Formula	C5H4ClFN2
Molecular Weight	146.55 g/mol
Synonyms	3-Amino-6-chloro-2-fluoropyridine; 2-Fluoro-6-chloropyridin-3-amine; 6-Chloro-2-fluoro-3-pyridinamine; 2-Fluoro-6-chloro-3-aminopyridine; 6-Chloro-2-fluoropyridin-3-ylamine; 1227600-05-6; 3-Pyridinamine, 6-chloro-2-fluoro-
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-Fluoropyridin-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable, ensuring traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.