Description

2-Fluoro-6-(Trifluoromethyl)Nicotinaldehyde is a high-value fluorinated pyridine derivative, serving as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl substituents, is engineered to impart enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. This compound is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active ingredients, particularly in agrochemical and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides and herbicides, where the fluorine atoms contribute to biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in catalytic processes and material science.
• Fluorinated Compound Library: Essential for combinatorial chemistry and high-throughput screening to discover new bioactive molecules.
• Chemical Research: Employed in academic and industrial labs for methodological studies in fluorination chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	2-Fluoro-6-(trifluoromethyl)nicotinaldehyde
CAS No.	1227599-54-3
Molecular Formula	C7H3F4NO
Molecular Weight	193.10 g/mol
Synonyms	2-Fluoro-6-(trifluoromethyl)pyridine-3-carbaldehyde; 3-Formyl-2-fluoro-6-(trifluoromethyl)pyridine; 2-Fluoro-6-trifluoromethylnicotinaldehyde; 6-(Trifluoromethyl)-2-fluoronicotinaldehyde; 2-Fluoro-6-(trifluoromethyl)-3-pyridinecarboxaldehyde; 1227599-54-3; Aldehyde, 2-fluoro-6-(trifluoromethyl)-3-pyridinecarbox-
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-6-(Trifluoromethyl)Nicotinaldehyde is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.