Description

4-Bromo-3-Fluoropyridin-2-Ol is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents adjacent to a hydroxyl group, makes it a versatile intermediate for introducing specific steric and electronic properties into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as components for OLEDs or conductive polymers.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A valuable scaffold for custom chemical synthesis services targeting niche and proprietary compounds.

Basic Information

Product Name	4-Bromo-3-Fluoropyridin-2-Ol
CAS No.	1227597-86-5
Molecular Formula	C5H3BrFNO
Molecular Weight	191.99 g/mol
Synonyms	2-Hydroxy-4-bromo-3-fluoropyridine; 4-Bromo-3-fluoro-2-pyridinol; 3-Fluoro-4-bromopyridin-2-ol; 4-Bromo-3-fluoro-2(1H)-pyridinone; 2-Pyridinol, 4-bromo-3-fluoro-; 4-Bromo-3-fluoropyridin-2(1H)-one
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-3-Fluoropyridin-2-Ol is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are provided with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.