Description

2,3-Difluoro-5-Methylpyridine is a high-purity fluorinated pyridine derivative, a crucial building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which allows for selective functionalization and incorporation into complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the difluoro-methylpyridine moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials requiring specific fluorine-substituted aromatic units.
• Chemical Biology Probes: Useful for synthesizing fluorinated analogs of bioactive molecules for metabolic studies and imaging applications.

Basic Information

Product Name	2,3-Difluoro-5-Methylpyridine
CAS No.	1227597-78-5
Molecular Formula	C6H5F2N
Molecular Weight	129.11 g/mol
Synonyms	5-Methyl-2,3-difluoropyridine; 2,3-Difluoro-5-picoline; 2,3-Difluoro-5-methylpyridine; 5-Methyl-2,3-difluoropyridine; 2,3-Difluoro-5-methyl-pyridine; Difluoromethylpyridine (isomer)
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-5-Methylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures material consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.